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Just imagine a world where humans no longer exist, who would take over? Well, it may not be another mammal. Believe it or not, octopuses could be the ones to dominate Earth after humans. 



Scientists have recently made a riveting claim that these eight-limbed, marine invertebrates could become the dominant species on Earth should homo sapiens vanish from existence. It's an intriguing idea, but how is it possible?



<h2 class="wp-block-heading" id="h-hypothetical-world-without-humans">Hypothetical world without humans</h2>



What if humanity were utterly wiped out through wars or climate change? It's a grim concept but it is fascinating to wonder about the <a href="https://www.earth.com/news/octopus-arms-inspire-more-human-like-robots/" target="_blank" rel="noreferrer noopener">potential successors</a> of our civilization.



According to leading experts, octopuses possess the "physical and mental attributes necessary" to evolve into the next civilization-building species.



<h2 class="wp-block-heading" id="h-octopus-taking-over-humans">Octopus taking over humans</h2>



Tim Coulson, a professor at the <a href="https://www.ox.ac.uk" target="_blank" rel="noreferrer noopener">University of Oxford</a>, presents an interesting case for these eight-legged creatures. His argument hinges on the octopuses' "dexterity, curiosity, ability to communicate with each other, and supreme intelligence."



These traits, according to Professor Coulson, equip octopuses with the potential to develop complex tools and methodologies necessary to birth a vast Atlantis-like civilization under the ocean.



<h2 class="wp-block-heading" id="h-why-not-primates">Why not primates?</h2>



One might think that primates, our closest relatives, have the best shot at stepping into our shoes if we were to vacate the world. They have opposable thumbs, use tools, and walk on two legs, right? But according to Professor Coulson, it's not that simple. 



He reasons that primates would face the same threats that could potentially wipe out humanity and thus are also at risk of extinction.



<h2 class="wp-block-heading" id="h-octopuses-competing-with-humans">Octopuses competing with humans</h2>



In an interview with The European magazine, Professor Coulson, who has held positions at institutions like <a href="https://www.imperial.ac.uk" target="_blank" rel="noreferrer noopener">Imperial College London</a> and <a href="https://www.cam.ac.uk" target="_blank" rel="noreferrer noopener">Cambridge University</a>, elaborates on why octopuses are a strong contender.



He refers to them as "the most intelligent, adaptable, and resourceful creatures on Earth," lauding their abilities to solve complex problems, manipulate objects, and even camouflage themselves with near-perfect precision.



Their decentralized nervous system and advanced neural structure, coupled with their exceptional problem-solving skills, make octopuses uniquely suited for an unpredictable world. 



Professor Coulson sees these intelligent cephalopods as an underappreciated contender who could step up as the planet's next intelligent species after humans.



<h2 class="wp-block-heading" id="h-adaptable-survivalists">Adaptable survivalists</h2>



If humans were to go extinct, most scientists concur that the creature to "replace" us should be dextrous. Dexterity, in this context, pertains to the ability to modify their environment and colonize the planet using complex tools, much like humans.



Octopuses' abilities to distinguish between real and virtual objects, solve puzzles, manipulate their surroundings, and adapt to a broad range of environments make them a viable candidate for future rulers of Earth. 



They are also adept at surviving in harsh conditions and are formidable hunters with a wide variety of prey including clams, shrimp, lobsters, fish, sharks, and even birds.



<h2 class="wp-block-heading" id="h-octopuses-and-human-like-settlements">Octopuses and human-like settlements</h2>



With relatively short lifespans, from between 1.5 to five years, one could argue that <a href="https://www.earth.com/news/the-octopus-has-mastered-the-art-of-multispecies-hunting/" target="_blank" rel="noreferrer noopener">octopuses</a> are on the back foot for the long evolutionary race. But here's a counterintuitive thought. 



What if their hasty reproduction and quick intellectual maturity actually give them an advantage in rapidly changing environments, thereby accelerating their evolutionary progress?



According to our Professor Coulson, while octopuses are unlikely to evolve into land-based animals due to their lack of a skeleton and associated challenges with mobility out of water, they could potentially develop underwater cities and towns akin to human settlements on land.



<h2 class="wp-block-heading" id="h-possible-yes-probable-maybe">Possible? Yes. Probable? Maybe.</h2>



In the end, as Professor Coulson reminds us, these are all just speculations. "It's important to remember that these are just possibilities, and that it's impossible to predict with any degree of certainty how evolution will unfold over extended periods."



However, given the <a href="https://www.earth.com/news/octopus-suckers-the-future-of-underwater-adhesives/" target="_blank" rel="noreferrer noopener">octopuses</a>' remarkable intelligence, adaptability, and diverse range of survival strategies, they could indeed emerge as a potential successor to humanity.



Now, whether the octopuses would build vast underwater cities or venture onto land to hunt terrestrial mammals is yet to be determined, and we may never really know.



For now, we will continue to marvel at these fascinating creatures and their potential for becoming the torchbearers of intelligent life on Earth, albeit in the far-flung future.



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Octopuses could dominate Earth if humans vanish

Just imagine a world where humans no longer exist, who...

Have you ever wondered why dog brains exhibit such a wide range of behaviors across breeds? Or why the tiny chihuahua, despite its small stature, seems to have as much personality as the large, stoic St. Bernard? 



In the world of mammals, a larger brain size typically indicates advanced cognition. However, our loyal companions, domestic dogs, seem to defy this logic. 



Dogs have brains that are, on average, 20% smaller than their wild ancestors, the gray wolves. However, domestic dogs showcase a variety of <a href="https://www.earth.com/news/dog-and-human-brains-sync-up-during-eye-contact/" target="_blank" rel="noreferrer noopener">cognitive skills</a> that are on par with - and sometimes even surpass - the wolves’ capabilities.



This discrepancy challenges some of our conventional assumptions about the connection between brain size and intelligence.



<h2 class="wp-block-heading" id="h-dog-brains-and-their-size">Dog brains and their size</h2>



Researchers from the <a href="https://www.umontpellier.fr/en/" target="_blank" rel="noreferrer noopener">University of Montpellier</a>, the University of Zurich, Naturhistorisches Museum Bern, and many other institutions recently embarked on a study to decipher the canine mystery.



The team set out to examine the potential link between breed function, behavior, and relative endocranial volume (REV) - an indicator of relative brain size.



The study included data from 1,682 dogs across 172 breeds, offering a diverse sample. A consistent method of measuring endocranial volumes was used across all dogs, ensuring reliable and accurate results.



Breed categorization was done based on traditional functions outlined by the American Kennel Club, with further analysis of phylogenetic clades. This comprehensive approach allowed the researchers to assess how historical and genetic factors play a role in <a href="https://www.earth.com/news/dogs-shrinking-brain-size-was-partially-caused-by-humans/" target="_blank" rel="noreferrer noopener">brain morphology</a>.



<h2 class="wp-block-heading" id="h-correlation-or-causation">Correlation or causation?</h2>



The results showed a noteworthy correlation between relative endocranial volume and breed function, body size, phylogenetic clade, and cranial shape. 



However, an interesting twist emerged - the correlation between cranial shape and REV was surprisingly weak. It turns out that skull shape alone is not a strong predictor of the size of the brain within.



<h2 class="wp-block-heading" id="h-dog-behavior-and-brain-size">Dog behavior and brain size</h2>



Surprisingly, relative endocranial volume was found to increase with fear, aggression, attention-seeking, and separation anxiety, yet was found to decrease with trainability.



Curiously, our tiny toy breeds, typically bred for companionship, possess the largest relative brain sizes compared to their body mass.



In contrast, working breeds, often selected for complex tasks like guarding, rescue, and policing, exhibit the smallest relative endocranial volume.



This inverse relationship suggests that complex skills, traditionally associated with higher cognition, don't necessarily require larger brains in dogs. What's more, cooperative behaviors showed no significant correlation with relative endocranial volume.



<h2 class="wp-block-heading" id="h-assessment-tools-and-behavioral-traits">Assessment tools and behavioral traits</h2>



The researchers used the Canine Behavioral Assessment and Research Questionnaire (C-BARQ), covering a broad spectrum of temperaments, from trainability to various forms of aggression and fear responses.



The study’s intriguing findings reveal the intricate relationship between a dog's brain structure, behavior, and breed. It suggests the incredibly adaptability of <a href="https://www.earth.com/news/talking-slower-helps-dogs-understand-what-humans-are-saying/" target="_blank" rel="noreferrer noopener">brain</a> size under domestication and the pressures of artificial selection.



The project was led by Dr. Anne-Claude Gingras of the <a href="https://www.uzh.ch/en.html" target="_blank" rel="noreferrer noopener">University of Zurich</a>, whose extensive work in the field of canine behavior and morphology played a significant role in this study.



<h2 class="wp-block-heading" id="h-implications-for-breeding-and-training">Implications for breeding and training</h2>



The research findings have significant implications for both breeding practices and training methodologies. 



Understanding the relationship between brain size, behavior, and breed function can refine breeding strategies to enhance specific traits without relying solely on physical attributes. 



For instance, selecting for desirable behaviors such as sociability or ease of training could be more effectively achieved by considering a breed's endogenous cognitive tendencies rather than focusing only on size or strength. 



Moreover, trainers could tailor their techniques based on a deeper awareness of the intrinsic behavioral propensities associated with different breeds, maximizing the potential of each dog through customized training regimes.



<h2 class="wp-block-heading" id="h-future-research-on-dog-brains">Future research on dog brains</h2>



The study opens new avenues for research into canine cognition, emphasizing the complexity of the relationship between brain morphology and behavior. 



Future investigations could expand the range of behaviors examined, incorporating modern techniques such as neuroimaging to delve deeper into the functional aspects of canine brains. 



Longitudinal studies might explore how domestic dogs' cognitive abilities evolve over time and in response to different environmental influences or societal changes. 



Additionally, comparative studies across other domesticated species may yield insights into the broader processes governing brain evolution in response to domestication. 



Through continued exploration, scientists can deepen our understanding of the domestication process and the unique capacities of our canine companions.



The study is published in the journal <a href="https://royalsocietypublishing.org/doi/10.1098/rsbl.2024.0342" target="_blank" rel="noreferrer noopener">Biology Letters</a>.



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Dog breed behavior linked to brain size

Have you ever wondered why dog brains exhibit such a...

Egyptian rituals have long captivated the imaginations of scholars and enthusiasts alike, and a recent breakthrough has demystified some of their most mysterious aspects.



In an incredible leap forward for archaeology and anthropology, a new study has provided tangible proof that the use of hallucinogenic mixtures was an integral part of this ancient civilization's sacred practices.



The physical evidence of hallucinogens was found in an Egyptian Bes mug, a rare relic stored in a collection at the Tampa Museum of Art.



These curious objects are distinctively adorned with the ferocious face of Bes, a protective deity linked to everything from fertility to magical healing.



<h2 class="wp-block-heading" id="h-tracing-the-roots-of-ritualistic-practices">Tracing the roots of ritualistic practices</h2>



This research didn't materialized overnight. The role of the Bes mugs in ancient Egyptian society has been a topic of debate for a long stretch of time.



“For a very long time now, Egyptologists have been speculating what mugs with the head of Bes could have been used for, and for what kind of beverage, like sacred water, milk, wine or beer,” noted Branko van Oppen, a museum curator at the Tampa Museum of Art.



The ubiquity of the mugs throughout different epochs made it tough to pinpoint their exact use and significance.



The cryptic puzzle finally began to fall into place when researchers from the <a href="https://www.usf.edu/" target="_blank" rel="noreferrer noopener">University of South Florida</a> embarked on an ambitious project to explore the unknown.



“There’s no research out there that has ever found what we found in this study,” said Davide Tanasi, lead author of the research paper that presents the findings.



The team managed to dissect the chemical signatures of a long-dried liquid inside one of the Tampa Museum's Bes mugs, providing a concrete clue to its past use.



<h2 class="wp-block-heading" id="h-the-secret-concoction-used-in-egyptian-rituals">The secret concoction used in Egyptian rituals</h2>



The result was nothing short of astounding. The researchers discovered a blend of <a href="https://www.earth.com/news/psychedelic-drugs-secreted-from-toad-skin-greatly-improve-cognitive-functioning/" target="_blank" rel="noreferrer noopener">psychedelic drugs</a>, bodily fluids, and alcohol inside the mug - a 'cocktail' likely used in a ritual re-enacting an Egyptian myth.



The mysterious brew was sweetened with popular ingredients of the time like honey, sesame seeds, pine nuts, licorice, and grapes, quite possibly to mimic the appearance of blood.



<h2 class="wp-block-heading" id="h-a-glimpse-into-ancient-life">A glimpse into ancient life</h2>



This astounding find has brought to life vivid images of the Greco-Roman period in <a href="https://www.earth.com/news/egypts-pyramids-were-built-along-a-buried-branch-of-the-nile-river/" target="_blank" rel="noreferrer noopener">Egypt</a>. 



The historical significance of the discovery underlines the importance of the Bes Chambers at Saqqara, a site apparently frequented by individuals hoping to confirm a successful pregnancy - a perilous phase in the ancient world.



“Egyptologists believe that people visited the so-called Bes Chambers at Saqqara when they wished to confirm a successful pregnancy because pregnancies in the ancient world were fraught with dangers," explained Van Oppen. 



He believes the special brew was likely used in a dream-vision inducing ritual during this fraught period.



This unusual study has helped us connect the dots between myths and reality.



“With this study, we’ve found scientific proof that the Egyptian myths have some kind of truth and it helps us shed light on the poorly understood rituals that were likely carried out in the Bes Chambers in Saqqara, near the Great Pyramids at Giza,” explained Tanasi.



Thus, the shroud of mystery surrounding ancient Egyptian rituals is gradually lifting, one artifact at a time.



<h2 class="wp-block-heading" id="h-symbolism-of-bes-in-egyptian-rituals">Symbolism of Bes in Egyptian rituals</h2>



The discovery of <a href="https://www.earth.com/news/peruvian-empire-kept-control-with-beer-and-hallucinogens/" target="_blank" rel="noreferrer noopener">hallucinogenic substances</a> within the Bes mug not only sheds light on the practices of ancient Egyptian rituals but also emphasizes the cultural weight carried by Bes, the deity represented on the artifact. 



Known for his lion-like visage and protective nature, Bes held an essential place in daily life and spiritual practices. He was not just a guardian deity; he was seen as a figure that could ward off evil spirits, promote <a href="https://www.earth.com/news/mediterranean-diet-improves-sperm-quality-and-fertility/" target="_blank" rel="noreferrer noopener">fertility</a>, and bring joy through music and dance.



In ancient Egypt, rituals involving Bes were believed to harness his powerful essence, particularly in times of vulnerability, such as childbirth and healing. 



The presence of hallucinogenic elements in the brew suggests that these ceremonies aimed to elevate participants' consciousness and induce a trance-like state for divine communication or visionary experiences.



Such practices aligned with the belief that connecting with deities like Bes could provide spiritual protection and guidance.



This new understanding of Bes' involvement in these rituals deepens our appreciation for how ancient <a href="https://www.earth.com/news/mystery-how-ancient-egyptians-built-pyramids-djoser-may-be-solved/" target="_blank" rel="noreferrer noopener">Egyptians</a> intertwined the mystical with the tangible, creating sacred ceremonies that reflected their belief in the interconnectedness of the human and divine realms.



The study was published in the journal <a href="https://search.app?link=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41598-024-78721-8&amp;utm_campaign=aga&amp;utm_source=agsadl2%2Csh%2Fx%2Fgs%2Fm2%2F4" target="_blank" rel="noreferrer noopener">Scientific Reports</a>.



Image Credit:&nbsp;Scientific Reports&nbsp;(2024).



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Hallucinogens were used in ancient Egyptian rituals

Egyptian rituals have long captivated the imaginations of scholars and...

We might like to think of ourselves as autonomous entities but, in reality, we're more like walking ecosystems, teeming with bacteria, viruses, and other microbes. It turns out that differences in these microbes might be as crucial to evolution and natural variation as genetic mutations are.



<h2 class="wp-block-heading" id="h-understanding-biological-variation">Understanding biological variation</h2>



This novel perspective was discussed in a recent publication by Seth Bordenstein, director of Penn State’s One Health Microbiome Center, who is a professor of biology and entomology and holds the Dorothy Foehr Huck and J. Lloyd Huck Endowed Chair in Microbiome Sciences.



He, along with 21 colleagues from around the globe, collectively known as the Holobiont Biology Network, propose that understanding the relationships between microbes and their hosts will lead to a more profound understanding of biological variation.



<h2 class="wp-block-heading" id="h-microbes-in-the-process-of-evolution">Microbes in the process of evolution</h2>



We've all heard the term evolution before, but what does it really mean? 



"The longstanding definition of <a href="https://www.earth.com/news/microbes-laid-the-foundation-for-early-life-on-earth/" target="_blank" rel="noreferrer noopener">evolution</a> is the process by which living things change over time due to gradual mutations and adaptations to their environments," Bordenstein explains.



These adaptations are commonly driven by natural selection, a process that involves advantageous traits being passed on down the lineage. 



However, when we incorporate the microbiome, the collection of all microbes in and on a host organism, the process of <a href="https://www.earth.com/news/discovery-evolution-not-random-gene-families-pangenome-influence-called-revolutionary/" target="_blank" rel="noreferrer noopener">evolution</a> becomes a whole lot more interesting and complex.



<h2 class="wp-block-heading" id="h-new-paradigm-holobiont-biology">New paradigm: Holobiont biology</h2>



Traditionally, we've kept the visible and invisible forms of life separate in the way we consider and study them. Many scientists still think of microbes in terms of background noise or minor contaminants.



But it turns out that this approach may have been selling the microbes short.



"Microbes are the base of the biosphere," Bordenstein explains. "Every host organism lives in contact and association with microbes, and those microbes can cause variation in traits."



This realization has given birth to a new concept - holobiont biology; a multidisciplinary and holistic understanding of how life's forms and functions depend upon relationships between microorganisms and their hosts.



Holobiont biology considers organisms and the microbes with which they are inseparably linked as a whole, rather than as separate entities.



<h2 class="wp-block-heading" id="h-how-does-the-biology-impact-classification">How does the biology impact classification?</h2>



The field of biology traditionally categorizes living things into taxa. But holobiont biology poses a challenging and exciting opportunity to rethink this framework.



"We’re making the case that organisms are not autonomous. They exist, by definition, always in association and in contact with <a href="https://www.earth.com/news/microbes-found-alive-inside-a-rock-after-2-billion-years-beneath-earth-surface/" target="_blank" rel="noreferrer noopener">microbes</a>," Bordenstein states.



This novel way of thinking could open doors to harness the power of the microbiome to improve health, resilience in environmental sustainability, and advancements in agriculture. 



Think of it: what if we could use microbes to combat chronic diseases like cancer or make agriculture more resistant to climate change?



<h2 class="wp-block-heading" id="h-revisiting-microbes-and-evolution">Revisiting microbes and evolution</h2>



Darwin's famous treatise, Origin of Species, is a cornerstone of modern biology. However, it was written with species of animals and plants in mind and did not consider the multitude of invisible microbes that are part of every individual macro-organism.



Now that we know so much more about the fundamental role of microbes in the biosphere, we can add a new layer to our understanding of evolution.



<h2 class="wp-block-heading" id="h-genetic-diversity-and-evolution">Genetic diversity and evolution</h2>



In the 1920s to 1940s, biology witnessed a revolution known as the Modern Synthesis, where Mendel's genetic laws were merged with Darwin's theory of evolution. This created a comprehensive explanation for how new variations of form and function develop over time.



We may well currently be at the cusp of another revolution, a post-Modern Synthesis. As Bordenstein points out, we're now factoring in the role of microbes in our understanding of genetics and evolution.



<h2 class="wp-block-heading" id="h-shifting-paradigms-in-life-sciences">Shifting paradigms in life sciences</h2>



How do we incorporate this new understanding of the importance of microbes in the biology and evolution of all organisms? The Holobiont Biology Network authors state that this needs to start with redefining and re-teaching biology.



"We’re thinking of animals and plants as a consortium of host and microbial cells that influence anatomy and physiology," explains Bordenstein.



There's also a need for new analytic tools to determine the contribution of microbes and how they interact with genetics to explain traits. Once we have these analytic tools in place, we can engineer microbes and microbiomes as much as we can engineer genes to yield better outcomes for organisms.



<h2 class="wp-block-heading" id="h-microbes-shaping-our-evolution">Microbes shaping our evolution</h2>



Microbes have been here for four billion years, and they outnumber the stars in the universe by orders of magnitude. There are more bacteria in your mouth than there are people on the planet. They have shaped our world in ways we are only just beginning to understand.



Research shows that they may also play a role in determining who is more likely to develop colon cancer, have high cholesterol levels or an average body mass index. After all, we contain not only our own genes, but also those of the billions of micro-organisms that live in and on us.  



"What we're learning today and over the past decade, is that sometimes microbes explain more biological trait variation in organisms than the genes do," Bordenstein says.



The future of biology lies not just in our genes, but in the characteristics of our associated <a href="https://www.earth.com/news/city-microbes-are-finding-surprising-new-ways-to-survive/" target="_blank" rel="noreferrer noopener">microbes</a> too. As we move forward, remember this: we're not lone entities. We're ecosystems.



So next time you brush your teeth, remember, you're not just maintaining dental hygiene; you're also managing an ecosystem!



The study is published in the journal <a href="https://www.science.org/doi/10.1126/science.ado2152" target="_blank" rel="noreferrer noopener">Science</a>.



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Humans are walking ecosystems and microbes rule their evolution

We might like to think of ourselves as autonomous entities...

Every organ in the human body is extraordinary, but the brain is an organ that often surpasses our understanding. It determines how we perceive the world, how we act, and how we remember. 



Our brain is hard at work - day and night. Yet, the brain is more than just an information-processing center; it's also the epicenter of our memories, emotions, stress, and fears.



Stress can lead to more than just a stiff neck or a racing heart. In extreme cases, it can influence our brain to create and retrieve memories in strange and unusual ways. 



Researchers at The Hospital for Sick Children (<a href="https://www.sickkids.ca/" target="_blank" rel="noreferrer noopener">SickKids</a>) have made fascinating discoveries about the relationship between stress, memory, and our brains' biological processes.



<h2 class="wp-block-heading" id="h-stress-and-memory-unsettling-connection">Stress and memory: Unsettling connection</h2>



Perhaps you've given a presentation that didn't go as planned. The next time you're due to present, you might feel stressed because your brain has linked this new presentation to the memory of the previous unsatisfactory experience. This is a type of <a href="https://www.earth.com/news/stress-is-contagious-and-this-applies-to-animals-too/" target="_blank" rel="noreferrer noopener">stress</a> tied to one memory.



However, stress from traumatic events, like witnessing violence or suffering from generalized anxiety disorder, can have a far-reaching impact. It can cause what is known as stress-induced aversive memory generalization. 



Here, unrelated stimuli can trigger frightening memories that seemingly have no connection to the original traumatic event. This phenomenon can have severe consequences for individuals who suffer from post-traumatic <a href="https://www.earth.com/news/stress-eats-away-our-brains-cognitive-defenses/" target="_blank" rel="noreferrer noopener">stress disorder</a> (PTSD).



<h2 class="wp-block-heading" id="h-memories-after-stress">Memories after stress</h2>



Dr. Sheena Josselyn and Dr. Paul Frankland, experts in the Neurosciences &amp; Mental Health program at SickKids, have identified the biological processes that result in stress-induced aversive memory generalization.



The experts have also found a potential intervention that could help restore the specificity of memory in individuals with PTSD.



“A little bit of stress is good, it’s what gets you up in the morning when your alarm goes off, but too much stress can be debilitating,” said Dr. Josselyn.



"We know that people with PTSD show fearful responses to safe situations or environments, and have found a way to limit this fearful response to specific situations and potentially reduce the harmful effects of PTSD."



<h2 class="wp-block-heading" id="h-understanding-the-mechanics">Understanding the mechanics</h2>



In a collaborative effort with Dr. Matthew Hill from the University of Calgary Hotchkiss Brain Institute, the research team was able to limit <a href="https://www.earth.com/news/chronic-stress-disrupts-gut-bacteria-and-fuels-cancer-progression/" target="_blank" rel="noreferrer noopener">stress</a>-induced aversive memory generalization to the specific, appropriate memory. This was achieved by blocking endocannabinoid receptors on interneurons.



To understand this process better, the team set up a preclinical model. They exposed subjects to a small amount of stress before a distressing event. 



This created a generalized fearful memory that could be triggered by unrelated safe situations, mirroring how PTSD manifests in humans.



Upon inspecting the subjects' memory engrams (the physical representations of a memory), the research team made an interesting discovery. 



Typically, engrams involve only a small number of neurons. However, the stress-induced memory engrams involved a significantly larger number of neurons.



When they examined these larger engrams more closely, the team found that stress resulted in increased endocannabinoid release in the brain, which disrupted the function of interneurons.



<h2 class="wp-block-heading" id="h-formation-of-fearful-memories">Formation of fearful memories</h2>



A significant bit of the puzzle lies in a previously overlooked area -- the endocannabinoid system. This system plays a key role in forming memories and associating experiences with specific behavioral outcomes.



Special "gatekeeper" interneurons in the amygdala, the emotional processing center of the brain, help constrain the size of the engram and, therefore, the specificity of the memory.



When too many endocannabinoids are released, these gatekeeper interneurons cannot function properly, leading to an increase in the size of the engram.



“Endocannabinoid receptors function like a velvet rope at an exclusive club. When stress induces the release of too many endocannabinoids, the velvet rope falls, causing more generalized aversive fearful memories to form," explained Dr. Josselyn.



"By blocking these endocannabinoid receptors just on these specific interneurons, we could essentially prevent one of the most debilitating symptoms of PTSD."



<h2 class="wp-block-heading" id="h-stress-induced-memory-engrams">Stress-induced memory engrams</h2>



In 2023, previous research published in the journal Science identified larger, more generalized memory engrams in the developing brain than in the adult brain, similar to stress-induced memory engrams.



As the experts continue to explore this unexpected connection between engram size, stress, and age, they also aim to understand how daily stressors might affect positive memories.



“The many biological functions and processes that make up the complexity of human memory are still being uncovered,” said Dr. Frankland.



“We hope that as we better understand human memory, we can inform real-world therapies for those with various psychiatric and other brain disorders throughout their lifespan.”



Indeed, as our understanding of the human brain continues to expand, so too do our hopes for revolutionary treatments and therapies. 



Through the diligent work of these researchers and others in the field, we may be able to fully unravel the mysteries of the brain, stress, and memory.



The study is published in the journal <a href="https://www.cell.com/cell/abstract/S0092-8674(24)01216-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424012169%3Fshowall%3Dtrue" target="_blank" rel="noreferrer noopener">Cell</a>.



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Stress changes how we recall memories, making them seem frightening

Every organ in the human body is extraordinary, but the...

Earth may once have had a vast ring system circling the planet, very similar to Saturn's rings, according to a recent study.



These rings seem to have formed around 466 million years ago, during a tumultuous era marked by intense meteorite bombardment known as the Ordovician impact spike.



This period was characterized by significant environmental changes, and the existence of rings may provide insight into our planet's dynamics at that time and its interactions with cosmic forces.



This thought-provoking theory stems from a recent study led by Professor Andy Tomkins of <a href="https://www.monash.edu/" target="_blank" rel="noreferrer noopener">Monash University</a>, who has dedicated years to investigating geological evidence and astronomical data.



This revelation could transform our understanding of Earth's geological evolution and its role within the <a href="https://www.earth.com/news/saturns-rings-may-have-formed-after-two-icy-moons-collided/" target="_blank" rel="noreferrer noopener">solar system</a>.



<h2 class="wp-block-heading" id="h-earth-rings-could-explain-impact-craters">Earth rings could explain impact craters</h2>



The research team based their hypothesis on the intriguing positions of 21 <a href="https://www.earth.com/news/asteroid-chicxulub-caused-dinosaurs-extinction-event-traced-to-origin-kuiper-belt/" target="_blank" rel="noreferrer noopener">asteroid impact craters</a>, all located within 30 degrees of the equator. This is a peculiar finding because, typically, impact craters are randomly distributed across the globe. 



However, in this case, more than 70% of Earth's landmass was outside this equatorial region during the <a href="https://www.earth.com/news/470-million-year-old-animal-fossils-discovered-in-frances-cabrieres-biota/" target="_blank" rel="noreferrer noopener">Ordovician period</a>, making the clustered craters an anomaly that standard geological theories cannot easily explain.



The team's idea is that this unusual pattern of impacts might be the result of a large asteroid having a close encounter with Earth. 



As it neared the planet, the asteroid would have crossed Earth's Roche limit -- a point where tidal forces become so strong that they can tear a celestial body apart. 



This would have led to the formation of a debris ring around Earth, similar to the rings that we see around gas giants <a href="https://www.earth.com/news/saturns-majestic-rings-will-vanish-in-just-six-months-from-now-2025/" target="_blank" rel="noreferrer noopener">like Saturn today</a>.



"Over millions of years, material from this ring gradually fell to Earth, creating the spike in meteorite impacts observed in the geological record," Tomkins explained. 



"We also see that layers in sedimentary rocks from this period contain extraordinary amounts of meteorite debris."



<h2 class="wp-block-heading" id="h-understanding-the-ordovician-period">Understanding the Ordovician period</h2>



<a href="https://www.earth.com/news/tiny-worms-sparked-explosive-evolutionary-period-of-life-on-earth/" target="_blank" rel="noreferrer noopener">The Ordovician period</a> happened about 485 to 444 million years ago. It was a time when a lot changed on Earth. Many new types of sea life evolved during this time, including the first fish. 



There were also lots of animals without backbones, like trilobites and early shellfish. 



Consequently, the oceans were teeming with life, and coral reefs started to form, creating homes for many different sea creatures.



The Earth itself changed a lot during the Ordovician period. 



At first, it was warm, like the tropics, but by the end of this time, there was a big ice age, which made sea levels drop significantly, resulting in widespread extinctions.



Despite these challenges, the Ordovician period set the stage for future evolutionary developments, leaving a lasting impact on the history of life on Earth.



<h2 class="wp-block-heading" id="h-connection-to-a-global-cooling-event">Connection to a global cooling event</h2>



But the implications of this discovery go beyond mere geology. The researchers speculate that this ring system might have had significant climate impacts, particularly contributing to a global cooling event known as the "Hirnantian Icehouse." 



This period, occurring near the end of the Ordovician, is recognized as one of the coldest times in the last 500 million years.



The idea is that the <a href="https://www.earth.com/news/new-ring-system-found-on-the-edge-of-our-solar-system/" target="_blank" rel="noreferrer noopener">ring system</a> could have cast a shadow over Earth, blocking sunlight and causing temperatures to drop. 



"The idea that a&nbsp;ring system&nbsp;could have influenced&nbsp;global temperatures&nbsp;adds a new layer of complexity to our understanding of how extra-terrestrial events may have shaped Earth's climate," Professor Tomkins explained.



<h2 class="wp-block-heading" id="h-how-the-study-was-conducted">How the study was conducted</h2>



To reach these conclusions, the team employed a Geographic Information System (GIS) to analyze the distribution of the Ordovician impact craters. 



They focused on stable, undisturbed cratons -- ancient, stable parts of the continental crust -- that were geologically capable of preserving craters from that era. 



By excluding areas that were buried under sediment, ice, or affected by tectonic activity, the researchers identified regions like Western Australia, Africa, the North American Craton, and parts of Europe as the most likely places to find these ancient craters.



Despite only 30% of the suitable land area being close to the equator, all the identified craters from this period were found in this region. 



The chances of this happening are like tossing a three-sided coin and getting the same side 21 times. This highly improbable distribution is what led the researchers to consider the possibility of an Earth ring system in the first place.



<h2 class="wp-block-heading" id="h-earth-rings-why-does-it-matter">Earth rings: Why does it matter?</h2>



This discovery doesn't just rewrite a chapter of Earth's history -- it opens an entirely new book. 



The idea that Earth may have had a <a href="https://www.earth.com/news/new-image-of-saturn-and-its-ring-spokes-from-the-hubble-space-telescope/" target="_blank" rel="noreferrer noopener">Saturn-like ring system</a> raises fascinating questions about how such features might have influenced not just our planet's climate but also the development of life itself.



Could other ancient ring systems have existed at different points in Earth's history? How might they have shaped the environment in ways we are only beginning to understand?



While the notion of Earth with rings might sound like science fiction, it's rooted in meticulous research and a willingness to question established theories.



This study, published in Earth and Planetary Science Letters, provides a fresh perspective on the dynamic interactions between our planet and the wider cosmos.



<h2 class="wp-block-heading" id="h-what-happens-next">What happens next?</h2>



The implications of this study extend well beyond the Ordovician period, urging us to reevaluate the broader influence of celestial events on Earth's evolutionary trajectory. 



As scientists continue to explore this new theory, they may uncover a past that is far more intricate and intertwined with cosmic phenomena than we previously thought.



Could similar rings have emerged during other pivotal moments in Earth's history, potentially influencing everything from climate patterns to the distribution of life? Only time, and science, will tell.



The full study was published in the journal <a href="https://www.sciencedirect.com/science/article/pii/S0012821X24004230?via%3Dihub" target="_blank" rel="noreferrer noopener">Earth and Planetary Science Letters</a>.



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Earth had a ring system like Saturn roughly 466 million years ago

Earth may once have had a vast ring system circling...

A prescription medication that has been available in the U.S. since 1992, which many people recognize for treating hair loss and enlarged prostate, seems to have another significant health benefit.



Recent research suggests that a drug called finasteride could lower cholesterol levels and reduce the risk of heart disease. That's a surprising twist for a drug that's been around for decades.



Curiosity led <a href="https://fshn.illinois.edu/directory/jaume6" target="_blank" rel="noreferrer noopener">Dr. Jaume Amengual</a>, an assistant professor in the Department of Food Science and Human Nutrition at the <a href="https://fshn.illinois.edu/" target="_blank" rel="noreferrer noopener">University of Illinois</a>, to explore this unexpected connection. 



After noticing something unusual in a national survey, he decided to dig deeper. 



"When we looked at the men taking finasteride in the survey, their <a href="https://www.earth.com/news/the-power-of-fish-oil-in-combating-high-cholesterol/" target="_blank" rel="noreferrer noopener">cholesterol levels</a> averaged 30 points lower than men not taking the drug. I thought we'd see the opposite pattern, so it was very interesting," Dr. Amengual enthused.



<h2 class="wp-block-heading" id="h-lowering-cholesterol-with-finasteride">Lowering cholesterol with finasteride?</h2>



The initial clue came from the <a href="https://www.cdc.gov/nchs/nhanes/index.htm" target="_blank" rel="noreferrer noopener">National Health and Nutrition Examination Survey</a> conducted between 2009 and 2016. 



This survey collects health information from thousands of Americans. In this data, men using finasteride as a <a href="https://www.earth.com/news/new-natural-cure-male-baldness-highly-effective-sugar-2-deoxy-d-ribose/" target="_blank" rel="noreferrer noopener">hair loss treatment</a> had significantly lower cholesterol levels compared to those who weren't on the medication. 



A 30-point difference is substantial and caught the researchers' attention. But observational studies have limitations. The sample size of men over 50 using finasteride was small. 



"This was not a clinical study in which you can control everything perfectly," Amengual noted. "It was more of an observation that led us to say, 'Okay, now we've seen this in people. Let's see what happens in mice.'"



<h2 class="wp-block-heading" id="h-from-observation-to-experimentation">From observation to experimentation</h2>



To get a clearer picture, the team turned to laboratory mice. Doctoral student <a href="https://www.linkedin.com/in/donald-molina-ba3099197/?locale=es_ES" target="_blank" rel="noreferrer noopener">Donald Molina Chaves</a> conducted experiments on mice predisposed to <a href="https://www.earth.com/news/fathers-diets-impact-the-heart-health-of-their-daughters/" target="_blank" rel="noreferrer noopener">atherosclerosis</a> -- a condition where arteries narrow due to plaque buildup. 



The mice were fed different doses of finasteride along with a high-fat, high-cholesterol diet.



"Mice that were given a high dose of finasteride showed lower <a href="https://www.earth.com/news/certain-gut-bacteria-lower-cholesterol-and-the-risk-of-heart-disease/" target="_blank" rel="noreferrer noopener">cholesterol levels</a> within the plasma as well as in the arteries," Molina Chaves said. "There were also fewer lipids and inflammatory markers in the liver." 



These findings suggested that finasteride doesn't just lower cholesterol in the blood but might also <a href="https://www.earth.com/news/lifestyle-choices-in-young-adulthood-impact-cognitive-ability-in-midlife/" target="_blank" rel="noreferrer noopener">reduce inflammation</a> and plaque formation in arteries.



While the highest dose had significant effects, it's not a dose humans would take. 



"It's an incredibly high level of the drug. But we use mice as a model, and they are extremely resistant to things that would kill any of us," Amengual explained. "So it is not that wild when you think about it that way." 



The results in mice provide a direction for future human studies.



<h2 class="wp-block-heading" id="h-finasteride-testosterone-and-heart-disease">Finasteride, testosterone, and heart disease</h2>



So why would a hair loss drug affect <a href="https://www.earth.com/news/new-study-eating-eggs-is-not-bad-for-your-health-despite-years-of-warnings/" target="_blank" rel="noreferrer noopener">cholesterol levels</a>? It comes down to hormones. 



Finasteride works by blocking a protein that activates testosterone, specifically reducing levels of <a href="https://www.earth.com/news/men-with-low-testosterone-have-a-higher-risk-of-mortality/" target="_blank" rel="noreferrer noopener">dihydrotestosterone (DHT)</a>. DHT is linked to hair loss, prostate enlargement, and, as it turns out, possibly heart disease.



"I was reading about this medication one day, and I started to notice that there were not many long-term studies of the implications of the drug," Amengual said. 



"Initially, it was just my own curiosity, based on the fact that hormone levels are known to have an effect on atherosclerosis, hair loss, and prostate issues. So, we decided to dig into it."



Testosterone and its derivatives can influence the development of atherosclerosis. By altering these hormone levels, finasteride might indirectly impact cholesterol metabolism and inflammation, leading to improved <a href="https://www.earth.com/news/social-expectations-of-men-are-bad-for-their-heart-health/" target="_blank" rel="noreferrer noopener">heart health</a>.



<h2 class="wp-block-heading" id="h-more-surprises-from-finasteride">More surprises from finasteride</h2>



Interestingly, these findings might benefit more than just men dealing with hair loss or prostate issues. 



Transgender individuals undergoing hormone therapy often face a higher risk of heart disease due to hormonal changes. 



Finasteride is sometimes prescribed during gender transitions to manage hair loss triggered by hormone treatments.



"Over the past decade, doctors have started prescribing this drug for individuals transitioning either from male to female or female to male. In both cases, the hormonal changes can trigger hair loss," Amengual said. 



"The interesting thing is that transgender people are also at a higher risk of <a href="https://www.earth.com/news/depression-and-cardiovascular-diseases-are-genetically-linked/" target="_blank" rel="noreferrer noopener">cardiovascular diseases</a>. So this drug could have a potential beneficial effect to prevent cardiovascular disease not only in cis men, but also in transgender individuals."



This opens up the possibility that finasteride could serve a dual purpose for transgender patients, helping with hair loss while also reducing heart disease risk.



<h2 class="wp-block-heading" id="h-what-s-the-catch-understanding-finasteride-risks">What's the catch? Understanding finasteride risks</h2>



Of course, no medication is without risks. Finasteride can cause side effects, and it's important to consider them. 



Some users experience <a href="https://www.earth.com/news/men-exhibit-better-sexual-health-eating-a-plant-based-vegan-diet/" target="_blank" rel="noreferrer noopener">sexual side effects</a> like decreased libido, erectile dysfunction, and reduced ejaculate volume. These effects happen because finasteride reduces DHT, which plays a role in sexual function.



There have also been reports of psychological effects such as depression, anxiety, and mood changes. While not everyone experiences these, they're important to monitor. 



Physical side effects can include breast tenderness or enlargement, rashes, and swelling in the hands or feet. Rarely, finasteride can affect liver enzymes, so regular medical check-ups are recommended.



A small percentage of users report persistent side effects even after stopping the medication, a condition referred to as Post-Finasteride Syndrome (PFS). 



Symptoms can include ongoing sexual dysfunction and psychological issues. Research is ongoing to understand and address these concerns.



<h2 class="wp-block-heading" id="h-what-the-future-holds-for-finasteride">What the future holds for finasteride</h2>



These discoveries suggest that finasteride could have a role in heart health beyond its current uses. More research is needed, though. 



Clinical trials involving people would help determine if the cholesterol-lowering effects seen in mice also occur in humans at practical doses.



"This was not a clinical study in which you can control everything perfectly," Amengual emphasized. "It was more of an observation that led us to say, 'Okay, now we've seen this in people. Let's see what happens in mice.'"



If future studies confirm these benefits, finasteride could become part of a strategy to prevent <a href="https://www.earth.com/news/artificial-sweetener-erythritol-sugar-substitute-linked-to-blood-clots-heart-disease/" target="_blank" rel="noreferrer noopener">heart disease</a>, especially in populations at higher risk.



<h2 class="wp-block-heading" id="h-a-new-hope-proceed-with-eyes-wide-open">A new hope? Proceed with eyes wide open</h2>



Finasteride has been around for a while, helping many with hair loss and prostate issues. Now, it might have a new role to play in promoting heart health. 



This could be significant not just for men but also for the transgender community and others at risk of cardiovascular disease.



As with any medical treatment, it's crucial to consult healthcare providers before making changes. Finasteride's potential benefits must be balanced with its risks. But this research opens up exciting possibilities.



The full study was published in the&nbsp;<a href="https://www.jlr.org/article/S0022-2275(24)00012-9/fulltext" target="_blank" rel="noreferrer noopener">Journal of Lipid Research</a>.



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Old drug now called a "magic pill" because it regrows hair and improves heart health

A prescription medication that has been available in the U.S....

THC, the main psychoactive ingredient in cannabis, is being used by more pregnant women as the legalization of recreational cannabis gains ground. 



Women who are expecting often use cannabis for morning sickness, lower back pain, or anxiety relief.



Recent figures indicate that up to 1 in 5 pregnant women in the U.S. now use cannabis. However, growing research suggests that THC exposure could pose significant risks to the developing fetus.



A recent study highlights how prenatal exposure to THC may increase the risk of opioid addiction later in life.



<h2 class="wp-block-heading" id="h-thc-rewires-the-fetal-brain">THC rewires the fetal brain</h2>



The preclinical animal study, led by researchers at the <a href="https://www.medschool.umaryland.edu/" target="_blank" rel="noreferrer noopener">University of Maryland School of Medicine</a> and published in the journal Science Advances, revealed that prenatal exposure to THC rewires the fetal brain.



According to the study, THC made certain <a href="https://www.earth.com/news/covid-19-makes-you-feel-moody-and-sad-by-depleting-dopamine/" target="_blank" rel="noreferrer noopener">dopamine</a> neurons hyperactive, resulting in a marked increase in dopamine release and an amplified response to reward-related cues, such as a signal indicating the availability of food or an opioid drug.



“Doctors are contending with an explosion of cannabis use, and the THC content has quadrupled from what it was a generation ago,” said Dr. Joseph Cheer, a professor of Neurobiology and Psychiatry at the University of Maryland School of Medicine.



“It demonstrates the enduring consequences that prenatal cannabis exposure exerts on the brain’s reward system, which ultimately results in a neurobiological vulnerability to <a href="https://www.earth.com/news/opioid-related-deaths-are-on-the-rise-among-young-people/" target="_blank" rel="noreferrer noopener">opioid</a> drugs.”



<h2 class="wp-block-heading" id="h-prenatal-exposure-to-thc">Prenatal exposure to THC</h2>



The study revealed that prenatal exposure to THC led to significant changes in the brain's reward system, particularly in male animals. 



These animals displayed an exaggerated surge in the "reward-seeking" brain chemical dopamine when exposed to opioid drugs during adolescence, compared to those not exposed to THC.



Even moderate doses of THC -- equivalent to one to two joints per day in humans -- altered how the fetal brain processed rewards, fostering behavior suggestive of increased opioid-seeking.



This behavior was confirmed by follow-up experiments where tiny sensors implanted in their brains detected heightened dopamine release and over-activation of neurons linked to reward-seeking behavior.



“These observations support the hypothesis of a hypersensitized ‘wanting’ system that develops in the brain after exposure to THC during <a href="https://www.earth.com/news/prenatal-cannabis-exposure-has-unexpected-effect-on-infant-language/" target="_blank" rel="noreferrer noopener">prenatal</a> development,“ said Dr. Cheer. 



"Interestingly, we found that this opioid-seeking phenotype occurs significantly more in males compared to females, and we are currently performing research with our colleagues at UMSOM to determine why this is the case.”



<h2 class="wp-block-heading" id="h-cannabis-health-benefits-outside-of-pregnancy">Cannabis health benefits outside of pregnancy</h2>



For those who are not pregnant, and don't expect to become pregnant soon, cannabis has been shown to provide mental and physical <a href="https://www.earth.com/news/cannabis-smokers-not-lazy-unmotivated-despite-stereotypes/" target="_blank" rel="noreferrer noopener">health benefits</a>.



Many people have found that cannabis can help relieve chronic pain. By interacting with the body's endocannabinoid system, compounds like THC and CBD in cannabis may <a href="https://www.earth.com/news/patients-with-chronic-pain-are-turning-to-cannabis-for-relief/" target="_blank" rel="noreferrer noopener">reduce discomfort</a> from conditions like arthritis, migraines, and neuropathic pain. 



This interaction can lead to improved daily functioning and a better quality of life for those who struggle with persistent pain.



Cannabis is also known for easing nausea and boosting appetite, which is particularly<a href="https://www.earth.com/news/cannabis-may-be-a-highly-effective-treatment-for-cancer-patients/" target="_blank" rel="noreferrer noopener"> beneficial for cancer patients</a> undergoing chemotherapy, or people dealing with conditions like HIV/AIDS. 



Some users report that it helps <a href="https://www.earth.com/news/chemical-found-in-cannabis-plants-can-actually-reduce-cannabis-induced-anxiety/" target="_blank" rel="noreferrer noopener">reduce anxiety</a> and <a href="https://www.earth.com/news/natures-sleep-aid-cannabinol-shows-promise-as-a-safe-sedative/" target="_blank" rel="noreferrer noopener">improve sleep</a>, making it a potential aid for insomnia or stress-related issues.



<h2 class="wp-block-heading" id="h-what-happens-next">What happens next?</h2>



Dr. Cheer and his colleague, Dr. Mary Kay Lobo, co-direct the Center for Substance Use in Pregnancy at the University of Maryland School of Medicine’s Kahlert Institute for Addiction Medicine. 



Their ongoing research aims to further understand the long-term impact of <a href="https://www.earth.com/news/prenatal-thc-exposure-linked-to-life-long-health-risks/" target="_blank" rel="noreferrer noopener">drug exposure during pregnancy</a>.



“We need to more fully understand the enduring effects of THC exposure in the womb and whether we can reverse some of the deleterious effects through CRISPR-based gene therapies or repurposed drugs," said study co-author Dr. Dean Mark T. Gladwin.



"We also need to provide better advice to pregnant patients, many of whom are using cannabis to help control anxiety because they think this drug is safer for their baby than traditional anti-anxiety medications.”



<h2 class="wp-block-heading" id="h-cannabis-pregnancy-and-health">Cannabis, pregnancy, and health</h2>



The findings suggest that there is a need for more exhaustive public health programs to educate pregnant women on the long-term effects that coincide with <a href="https://www.earth.com/news/record-number-of-americans-are-high-on-marijuana-at-work/" target="_blank" rel="noreferrer noopener">marijuana</a> exposure during pregnancy. 



Previous studies on cannabis use during pregnancy have also raised significant concerns about its potential impacts on fetal development and maternal health.



For example, studies have linked prenatal cannabis exposure to deficits in attention, memory, and executive functioning in children. 



Furthermore, cannabis use during pregnancy is associated with an increased risk of low birth weight, which can lead to complications such as developmental delays and long-term health issues.



Guidelines on pregnancy and provision of adequate resources for pregnant women could be created and harmonized in collaboration between healthcare providers, researchers, and policymakers.



Investments in supplemental research, which would include human studies, may also clarify how exposures to THC impact the fetal brain in its developing state. 



The study is published in the journal <a href="https://www.science.org/doi/10.1126/sciadv.adq5652" target="_blank" rel="noreferrer noopener">Science Advances</a>.



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Cannabis use during pregnancy rewires the fetal brain

THC, the main psychoactive ingredient in cannabis, is being used...

When we think of oxytocin, the image of a warm embrace or the deep connection between a mother and her child often comes to mind. 



This hormone, often dubbed the "love hormone" or "cuddle hormone," is famous for its role in fostering emotional bonds and promoting feelings of trust and empathy. 



But recent studies suggest that oxytocin might be doing much more behind the scenes, especially when it comes to how we learn and remember. And more surprisingly, it may also help cure addiction.



Leading this exciting exploration are Professor Akiyoshi Saitoh and researcher Junpei Takahashi from the <a href="https://www.tus.ac.jp/en/" target="_blank" rel="noreferrer noopener">Tokyo University of Science</a>, and Meredith Berry, Ph.D. from the <a href="http://www.ufl.edu/" target="_blank" rel="noreferrer noopener">University of Florida</a>. 



They have been delving into the intricate ways oxytocin influences our brains, potentially paving the way for new treatments for conditions like dementia and <a href="https://www.earth.com/news/brain-discovery-offers-hope-for-tackling-opioid-addiction/" target="_blank" rel="noreferrer noopener">opioid addiction</a>.



<h2 class="wp-block-heading" id="h-oxytocin-s-role-in-memory">Oxytocin's role in memory</h2>



While oxytocin is well-known for its impact on social behaviors, its role in cognitive functions is less understood. 



Professor Saitoh's team wanted to uncover whether oxytocin could be a key player in <a href="https://www.earth.com/news/how-does-our-brain-form-long-term-memories/" target="_blank" rel="noreferrer noopener">how memories are formed</a> and retained. 



“Previously we had suggested that oxytocin may be a new therapeutic candidate for dementia based on studies using a mouse model of <a href="https://www.earth.com/news/alzheimers-disease-attacks-the-brain-in-two-separate-phases/" target="_blank" rel="noreferrer noopener">Alzheimer’s disease</a>,” he shared. 



“To investigate this further, in this study, we examined the role of endogenous oxytocin in mouse cognitive function.”



Using advanced techniques, the researchers specifically activated oxytocin neurons in certain brain regions of mice. 



They then evaluated the mice's memory using tasks designed to test recognition and recall, like the <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/novel-object-recognition-test" target="_blank" rel="noreferrer noopener">Novel Object Recognition Task</a>. 



This method helps scientists determine how well an animal can recognize a new object compared to one they've seen before.



<h2 class="wp-block-heading" id="h-peering-into-the-brain-s-memory-centers">Peering into the brain's memory centers</h2>



The brain is a complex network, and understanding how different areas interact is crucial. 



The team noticed that when they stimulated oxytocin neurons in the paraventricular hypothalamic nucleus (PVN), there was increased activity not only there but also in the supramammillary nucleus (SuM). 



These regions are connected and play roles in memory and <a href="https://www.earth.com/news/music-causes-similar-emotional-experiences-and-sensations-in-all-cultures/" target="_blank" rel="noreferrer noopener">emotional responses</a>.



By observing markers that indicate neuron activation, they confirmed that these areas were more active following their interventions. 



Interestingly, while the mice didn't show significant changes in short-term memory tasks, there was a noticeable improvement in long-term memory, particularly in recognizing new objects.



<h2 class="wp-block-heading" id="h-oxytocin-connection-to-dementia">Oxytocin connection to dementia</h2>



These findings have significant implications. <a href="https://www.earth.com/news/herbal-medicine-shows-potential-to-treat-and-prevent-dementia/" target="_blank" rel="noreferrer noopener">Dementia</a>, including Alzheimer's disease, affects millions worldwide, leading to memory loss and cognitive decline. 



Understanding how oxytocin influences memory could lead to new therapies that slow down or mitigate these effects.



There's also a broader social context. Many believe that loneliness and lack of social interaction can worsen <a href="https://www.earth.com/news/dementia-was-extremely-rare-in-ancient-times-so-why-is-it-now-so-prevalent/" target="_blank" rel="noreferrer noopener">dementia symptoms</a>. 



“There is a widely acknowledged belief that dementia tends to advance more rapidly in settings where individuals experience loneliness or limited social engagement. However, the scientific underpinnings of this phenomenon have remained largely elusive," Professor Saitoh pointed out.



By highlighting oxytocin's role, the research suggests that stimulating social interactions -- or even directly targeting oxytocin pathways -- might help in <a href="https://www.earth.com/news/diabetes-drugs-may-protect-against-dementia/" target="_blank" rel="noreferrer noopener">managing dementia</a>.



<h2 class="wp-block-heading" id="h-oxytocin-and-opioid-addiction">Oxytocin and opioid addiction</h2>



Across the globe, another team is exploring oxytocin's potential in a different arena. 



At the University of Florida, researchers are investigating whether a synthetic version of oxytocin can help curb opioid addictions, a pressing issue affecting many communities.



“The idea is that physicians could potentially prescribe, in combination, an opioid and oxytocin as an acute <a href="https://www.earth.com/news/mindfulness-meditation-is-a-powerful-weapon-against-chronic-pain/" target="_blank" rel="noreferrer noopener">pain management</a> option, while at the same time lessening the likelihood of developing an addiction to opioids,” explained Dr. Meredith Berry.



Working alongside Dr. Yenisel Cruz-Almeida and Dr. Natalie Ebner, Dr. Berry is examining whether oxytocin can reduce pain effectively while also decreasing the desire for prolonged opioid use.



<h2 class="wp-block-heading" id="h-opioids-are-still-a-huge-problem">Opioids are still a huge problem</h2>



Opioid addiction has become a significant public health concern, particularly in the United States. 



Prescription opioids, while effective for managing pain, carry a high risk of addiction. Older adults, who often require pain management, can be particularly vulnerable.



By exploring alternatives that reduce pain without the same addictive potential, researchers hope to offer safer options for patients. 



Oxytocin's natural role in promoting well-being might counteract some of the addictive properties of opioids.



<h2 class="wp-block-heading" id="h-healing-addiction-with-oxytocin">Healing addiction with oxytocin</h2>



In their carefully designed study, the University of Florida team is working with participants aged 55 to 85 who have some history of opioid use. 



In a controlled setting, these participants will receive synthetic oxytocin via a nasal spray or a placebo after taking oral <a href="https://www.earth.com/news/experts-identify-a-route-to-safer-painkillers/" target="_blank" rel="noreferrer noopener">oxycodone</a>.



The researchers will collect data on how much the participants enjoy the drugs, as well as monitor physical responses like heart rate and breathing. 



They'll also assess cognitive and emotional reactions. To measure pain responses, they will apply mild mechanical pressure to the thighs and expose the hands to varying temperatures.



Dr. Ebner will analyze mood changes and cognitive effects, while Dr. Cruz-Almeida will examine how the drugs affect pain responses. 



Dr. Berry will evaluate the potential for reduced opioid addiction based on these findings. Physicians from the university's College of Medicine are involved to ensure participant safety.



<h2 class="wp-block-heading" id="h-is-oxytocin-the-wonder-drug-of-the-future">Is oxytocin the "wonder drug" of the future?</h2>



The combined efforts of these research teams highlight the versatility of oxytocin, putting the "love hormone" on the radar of scientists of all disciplines around the world.



From potentially enhancing memory and combating dementia to offering new strategies for pain management without the high risk of addiction, oxytocin's benefits could be far-reaching.



These studies underscore the importance of looking beyond traditional uses of well-known substances. Sometimes, the key to solving complex health issues lies in re-examining what we thought we knew.



The journey of oxytocin from a simple "love hormone" to a potential powerhouse in medical treatment is a testament to the ever-evolving nature of science. 



As researchers like Professor Saitoh and Dr. Berry continue their work, we can look forward to new discoveries that might improve the quality of life for many.



The full study was published in the journal <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0294113" target="_blank" rel="noreferrer noopener">PLOS One</a>.



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"Cuddle hormone" fosters love, boosts memory, and now also cures addiction

When we think of oxytocin, the image of a warm...

Eggs have been a highly debated topic in the world of health and nutrition. They have been hailed as superfoods, then vilified as cholesterol-packed enemies, before being welcomed back into the "good" food group.



A recent study further strengthens eggs’ position in the "good" basket, revealing that these well-known breakfast staples might be more beneficial for our brains than we once realized.



<h2 class="wp-block-heading" id="h-eggs-as-brain-food">Eggs as brain food</h2>



A research team from the <a href="https://ucsd.edu" target="_blank" rel="noreferrer noopener">University of California-San Diego</a> has found that older women who indulge in eggs every week may notice less memory loss and a slower decline in executive <a href="https://www.earth.com/news/brain-health-may-literally-be-a-state-of-mind/" target="_blank" rel="noreferrer noopener">brain functions</a> over time. 



This adds to the growing body of research suggesting that eggs, despite being notorious for their high cholesterol content, could potentially promote cognitive health in certain demographics.



<h2 class="wp-block-heading" id="h-eggs-and-brain-health">Eggs and brain health</h2>



The findings, published in the scientific journal Nutrients, are based on a study involving 890 adults aged 55 and above from the Rancho Bernardo study in California.



Throughout 1988 to 1991, the participants diligently recorded their egg consumption and underwent a series of <a href="https://www.earth.com/news/physical-activity-instantly-boosts-your-brain-speed-by-years/" target="_blank" rel="noreferrer noopener">cognitive tests</a>. This process was repeated from 1992 to 1996, evaluating their global cognition, executive function, and semantic memory.



<h2 class="wp-block-heading" id="h-women-and-eggs-tracing-the-connection">Women and eggs: Tracing the connection</h2>



Interestingly, the data revealed that among women, those who consumed more eggs each week showed less decline in category fluency, which is a critical test for verbal abilities and executive function, over the four-year period. 



This correlation persisted even after considering a variety of factors such as age, education, lifestyle behaviors, cholesterol levels, protein intake, and calorie intake.



The research suggests that the optimal egg intake for older women hovers around five eggs per week. So, you could say that an egg a day could potentially keep cognitive decline at bay.



<h2 class="wp-block-heading" id="h-egg-intake-in-women">Egg intake in women</h2>



"Women in the highest category of egg intake would have a half-point less decline in category fluency score over 4 years compared to women who never consumed eggs," noted the researchers, Donna Kritz-Silverstein and Ricki Bettencourt.



"Although small, this association was still significant after further adjustment for behaviors, cholesterol, and calorie and protein intake, as well as after additional adjustment for diabetes and hypertension."



<h2 class="wp-block-heading" id="h-why-do-eggs-stand-out">Why do eggs stand out?</h2>



The concrete reason behind eggs being beneficial for <a href="https://www.earth.com/news/your-brain-literally-changes-based-on-daily-activities-and-lifestyle/" target="_blank" rel="noreferrer noopener">cognitive health</a> isn't entirely clear, but the researchers offer some promising leads. 



Nutrients like choline, lutein, and zeaxanthin found in eggs have been associated with improved brain health in previous research. Furthermore, the high-quality protein in eggs could help maintain neuronal structure and function.



While eggs do contain dietary cholesterol, they have relatively low levels of harmful saturated fat compared to meats. This might permit eggs to offer cognitive benefits without the potential drawbacks associated with high-cholesterol foods.



"The lack of cognitive decline with egg consumption is reassuring and suggests that despite having high levels of dietary cholesterol, eggs do not have a detrimental effect and may even have a role in the maintenance of cognitive function over time," concluded the researchers.



<h2 class="wp-block-heading" id="h-study-limitations-and-future-research">Study limitations and future research</h2>



As this was an observational study, further research is necessary to validate a cause-effect relationship. 



Yet, these findings contribute to the ever-growing body of evidence challenging the previously held notion that eggs should be strictly limited in the diet, especially for older adults aiming to preserve their mental clarity.



The researchers analyzed the relationship between egg intake and changes in cognitive test scores over the four-year period. Men and women were analyzed separately to account for potential sex differences, and the results were adjusted to control for a variety of factors.



<h2 class="wp-block-heading" id="h-breakfast-for-brain-health">Breakfast for brain health</h2>



One key finding was that among women, greater egg consumption was associated with less decline over the four years in category fluency. Women who reported eating five or more eggs per week saw about a half-point less decline in their category fluency scores compared to women who never ate eggs.



Moreover, there were no significant links found between egg intake and cognitive changes in men, emphasizing the need for further investigations into these gender differences.



These findings suggest that what we eat can greatly affect our health. Eggs, with their nutrients like choline, lutein, zeaxanthin, and high-quality protein, might be the best breakfast for <a href="https://www.earth.com/news/walking-is-a-powerful-tool-to-boost-brain-health-and-overall-well-being/" target="_blank" rel="noreferrer noopener">brain</a> health.



The study is published in the journal <a href="https://www.mdpi.com/2072-6643/16/16/2765" target="_blank" rel="noreferrer noopener">Nutrients</a>.



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Eggs may slow memory decline and support brain health

Eggs have been a highly debated topic in the world...

The influence of synthetic plastic on our planet is concerning, to say the least. It's everywhere - from the depths of our oceans to the food we eat, even finding its way into our bodies. But, Avinash Manjula-Basavanna, a seasoned research scientist at Northeastern University, sees "MECHS" as a solution. 



"The kind of impact that human-made materials are making on the living world is resulting in&nbsp;climate change, pollution and more," he says. 



"One of the ways that we are able to address this is to make materials sustainable and also make materials which are smart or intelligent."



<h2 class="wp-block-heading" id="h-birth-of-a-new-bioplastic">Birth of a new bioplastic</h2>



Joining forces with Neel S. Joshi, an associate professor of chemistry and chemical biology at Northeastern, Manjula-Basavanna gave birth to a new bioplastic named MECHS.



It stands for Mechanical Engineered Living Materials with Compostability, Healability, and Scalability.



The team recently showcased their discovery in the journal Nature Communications. Here, they articulated their unique work with engineered living materials, living cells that produce functional <a href="https://www.earth.com/news/plastic-pollution-is-changing-the-entire-earth-system/" target="_blank" rel="noreferrer noopener">materials</a>.



<h2 class="wp-block-heading" id="h-wonders-of-bioplastic">Wonders of bioplastic</h2>



What makes MECHS stand out? Manjula-Basavanna and Joshi gave us two major reasons.



Firstly, MECHS exhibits the beauty of nature-inspired solutions, with the ability to regenerate, regulate themselves, and respond to external stimuli such as light. 



The second reason is even more significant in today's context. Unlike the harmful plastics choking our planet and bodies, MECHS is biodegradable in water and even in a compost bin. 



"Right now we use a lot of conventional nonbiodegradable plastics for applications they don't need to be used in at all," Joshi says. "If we replace that with our <a href="https://www.earth.com/news/major-plastic-pollution-lurks-beneath-the-surface-of-rivers/" target="_blank" rel="noreferrer noopener">plastic</a>, you could just flush it down the toilet and it would biodegrade."



<h2 class="wp-block-heading" id="h-engineered-living-materials">Engineered living materials</h2>



Until now, such engineered living materials haven't been scalable for broad production. Enter MECHS.



Essentially, it's comprised of engineered E. coli bacteria intertwined with a fiber matrix, crafted into a paper- or film-like material. 



The fibrous structure gives MECHS some desirable properties. For instance, the bioplastic can stretch like plastic wrap and be genetically engineered for variable stiffness. And, quite fascinatingly, it has self-healing capabilities.



But the real cherry on top? MECHS is fully dissolvable, be it in large amounts of water or a compost bin. It dissolves rapidly, much faster than other existing biodegradable plastics. Plus, it can be mass-produced similarly to paper.



<h2 class="wp-block-heading" id="h-potential-applications">Potential applications</h2>



The scientific marvels envision MECHS as the solution to "primary packaging." This includes the plastic cover protecting your new iPhone or the detergent pods for your appliances. Imagine MECHS wrapped around a pot plant, slowly breaking down and releasing proteins to fertilize the plant!



Addressing the global problem of plastic pollution, Manjula-Basavanna sees a strong potential for MECHS in plastic packaging, which covers almost one-third of the plastic market. 



He observes that such packaging’s lifespan could last a few days to two years, but the petrochemical plastics used can take hundreds of years to biodegrade.



"For such a short lifespan of packaging, the petrochemical plastics that can take hundreds of years to biodegrade are unnecessary in many cases and thus a sustainable alternative like MECHS due to its biodegradability, flushability, and mechanical tunability could be a game changer," says Manjula-Basavanna.



<h2 class="wp-block-heading" id="h-challenges-in-adopting-mechs">Challenges in adopting MECHS</h2>



While MECHS presents a revolutionary solution to the global plastic crisis, adopting this technology on a large scale is not devoid of challenges. One primary concern lies in the genomic stability of the engineered E. coli bacteria used in MECHS. 



Scientists must ensure that the bacteria remain safe and stable under various environmental conditions to avoid unintended consequences. Additionally, transitioning industries reliant on traditional plastics to MECHS involves overcoming significant economic and logistical barriers. 



Production facilities worldwide may need to adopt new techniques and infrastructure to accommodate this novel material, potentially incurring considerable costs in the short term. 



Furthermore, public perception and regulatory hurdles need to be navigated to gain trust and approval for its widespread use.



<h2 class="wp-block-heading" id="h-future-of-sustainable-materials">Future of sustainable materials</h2>



Looking to the future, the innovations around MECHS signal a burgeoning era of sustainable and adaptable materials capable of transforming industries. 



As research into living materials progresses, new possibilities emerge, such as enabling the development of dynamic, adaptable materials for technologies yet to be imagined. 



Building on their success with MECHS, Manjula-Basavanna and Joshi envision an expanding palette of biodegradable materials, each tailored for specific applications ranging from environmental conservation to health care. 



Their work emphasizes collaboration across disciplines - bridging biology, chemistry, and engineering - to advance sustainable solutions.



Ultimately, MECHS is a testament to how embracing nature-inspired innovation can lead to breakthroughs with the power to <a href="https://www.earth.com/news/plastic-on-beaches-is-now-visible-from-space/" target="_blank" rel="noreferrer noopener">reshape our relationship with the materials</a> we use and the environment we inhabit.



The study is published in the journal <a href="https://www.nature.com/articles/s41467-024-53052-4" target="_blank" rel="noreferrer noopener">Nature Communications</a>.



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Nature-inspired solutions: New bioplastic dissolves rapidly in water

The influence of synthetic plastic on our planet is concerning,...

Are we alone in the universe? Does alien life exist in our galaxy and beyond? Today, as technology continues to rapidly advance, the answers to these profound questions are now closer than ever before. 



Astronomers recently devised a new model they're calling the "formula for life." 



The experts hope this tool will calculate the chances of intelligent life existing in our universe and even predict the potential for alien life to emerge in future universes.



<h2 class="wp-block-heading" id="h-next-generation-of-intelligent-life">Next generation of intelligent life </h2>



According to this new calculation model, the likelihood of life beyond our galaxy sits at 27 percent, which may let down the 65 percent of American adults who firmly believe in extraterrestrial life.



Interestingly, the chances of <a href="https://www.earth.com/news/are-aliens-sending-radio-signals-to-each-other/" target="_blank" rel="noreferrer noopener">intelligent life</a> existing within our own Milky Way are even lower -- just 23 percent.



These estimates come from the concerted efforts of researchers at the <a href="https://search.app?link=https%3A%2F%2Fwww.ed.ac.uk%2F&amp;utm_campaign=aga&amp;utm_source=agsadl2%2Csh%2Fx%2Fgs%2Fm2%2F4" target="_blank" rel="noreferrer noopener">University of Edinburgh</a> and the <a href="https://iubtgedu.org/" target="_blank" rel="noreferrer noopener">University of Genevieve</a>. 



The study suggests that star formation and the evolution of large-scale planets might intertwine to quietly "form the next generation of intelligent life."



<h2 class="wp-block-heading" id="h-frank-drake-s-famous-equation">Frank Drake's famous equation</h2>



The <a href="https://en.wikipedia.org/wiki/Drake_equation" target="_blank" rel="noreferrer noopener">Drake Equation is a formula</a> that estimates the number of active, communicative extraterrestrial civilizations in our galaxy. 



<a href="https://en.wikipedia.org/wiki/Frank_Drake" target="_blank" rel="noreferrer noopener">Frank Drake</a> introduced it in 1961 as a way to break down the complex question of alien life into more manageable parts. 



The equation considers factors like the average rate of star formation, the fraction of stars with planetary systems, the number of planets that could support life, and the likelihood of life developing intelligence and technology to communicate across space.



By tweaking the values of these factors, we can explore different possibilities about how common or rare intelligent life might be in the Milky Way. 



It's not about getting an exact number but sparking discussions and guiding research in astronomy and the search for extraterrestrial intelligence (<a href="https://www.seti.org" target="_blank" rel="noreferrer noopener">SETI</a>). 



<h2 class="wp-block-heading" id="h-dark-energy-and-the-potential-for-alien-life">Dark energy and the potential for alien life</h2>



To understand the potential of other life forms, the team devised a theoretical model that leans heavily on the <a href="https://www.earth.com/news/are-humans-only-intelligent-life-milky-way-galaxy-possible-not-likely/" target="_blank" rel="noreferrer noopener">Drake Equation</a>.



The researchers emphasized that their calculations do not suggest a number of intelligent life forms but rather estimate the likelihood of their <a href="https://www.earth.com/news/dark-oxygen-in-the-deep-sea-may-hold-clues-about-alien-life/" target="_blank" rel="noreferrer noopener">existence</a>.



Their estimation process takes into account dark energy, which comprises over two-thirds of the universe and fuels its expansion.



"Understanding dark energy and the impact on our universe is one of the biggest challenges in cosmology and fundamental physics," said lead researcher Dr. Daniele Sorini, affiliated with <a href="https://www.durham.ac.uk" target="_blank" rel="noreferrer noopener">Durham University</a>’s Institute for Computational Cosmology.



<h2 class="wp-block-heading" id="h-potential-for-future-alien-life">Potential for future alien life</h2>



In addition to the probabilities of current extraterrestrial life, the researchers' model also accommodates for alien life forms that don't exist yet but could develop in the future. 



To do this, they calculated the amount of ordinary matter that combined to form stars across the universe's history, stretching back a staggering 13.8 billion years.



It seems the chances of <a href="https://www.earth.com/news/cosmic-connection-aliens-could-make-contact-by-2029/" target="_blank" rel="noreferrer noopener">intelligent life</a> appearing in universes beyond our own also hover at around 27 percent. 



"Surprisingly, we found that even a significantly higher dark energy density would still be compatible with life, suggesting we may not live in the most likely of universes," said Dr. Sorini.



<h2 class="wp-block-heading" id="h-interplay-of-gravity-and-alien-life">Interplay of gravity and alien life</h2>



Another intriguing factor in cosmic life creation is gravity's role. <a href="https://www.earth.com/news/theory-gravity-exists-without-mass-so-dark-matter-does-not-exist/" target="_blank" rel="noreferrer noopener">Gravity influences</a> the formation of stars and galaxies, effectively setting the stage for potential habitats where life could develop.



The extent of gravity's influence in these processes highlights its importance, not just in structural formation, but in setting conditions that could favor the emergence of life. 



Existing research suggests that regions with <a href="https://www.earth.com/news/central-theory-of-quantum-gravity-is-modeled-in-the-laboratory/" target="_blank" rel="noreferrer noopener">optimal gravity balance</a> might support complex planetary systems, paving the way for biological evolution.



As scientists continue to explore the mysteries of the universe, understanding the precise role of gravity will add another layer to our comprehension of life's cosmic potential.



<h2 class="wp-block-heading" id="h-what-happens-next">What happens next?</h2>



Modeling the probability of intelligent life in other universes opens up numerous avenues for future research.



Scientists are now challenged to refine these models further, grounding them in observations and experiments to reach more precise conclusions.



Such work may involve advancing our understanding of <a href="https://www.earth.com/news/new-evidence-suggests-that-dark-energy-comes-from-black-holes/" target="_blank" rel="noreferrer noopener">dark matter and energy</a> -- components of the universe that remain elusive yet crucial to grasping the cosmic puzzle.



This pursuit could bridge the gap between theoretical physics and cosmology, bringing them closer within the realms of empirical science.



<h2 class="wp-block-heading" id="h-from-speculation-to-exploration">From speculation to exploration</h2>



"It will be exciting to employ the model to explore the emergence of life across different universes and see whether some fundamental questions we ask ourselves about our own universe must be reinterpreted," noted study co-author Lucas Lombriser, a professor at the University of Genevieve.



If this research can help us to better understand our own universe and its likelihood for hosting life, it seems we have come a long way from wild speculation to measured investigation into our place in the cosmos.



So, what does this all mean for us? Are we on the brink of making contact with alien life forms? While the research findings might lead some to temper their expectations, the search for extraterrestrial life continues.



In the end, we need to remember that the universe is vast, mind-bogglingly diverse, and still largely unexplored. 



The <a href="https://www.earth.com/news/finding-alien-life-searching-for-color-purple-not-green/" target="_blank" rel="noreferrer noopener">discovery of life beyond Earth</a> -- both as we know it and beyond our current comprehension -- remain a thrilling frontier in scientific exploration.



The study is published in the journal <a href="https://academic.oup.com/mnras/article/535/2/1449/7896079?login=false#493432585" target="_blank" rel="noreferrer noopener">Monthly Notices of the Royal Astronomical Society</a>.



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Chances that intelligent alien life exists are updated by new AI model

Are we alone in the universe? Does alien life exist...

Date	Citation Page	Title
01/23/1984	49 FR 2779 2783	List 10 Foreign Mammals as End. Species, & Withdrawal of 1 Species; 49 FR 2779-2783
03/01/1983	48 FR 8514 8517	Proposed Listing of 12 Species of Foreign Mammals as End. Species; 48 FR 8514-8517